Cart
sales@molnova.com
FABPs ligand 6
CAS No. 2988135-14-2
FABPs ligand 6( —— )
Catalog No. M35676 CAS No. 2988135-14-2
FABPs ligand 6 (MF6) is a selective inhibitor of FABP5 and FABP7 that reduces levels of oxidative stress in the mouse spinal cord as well as lipopolysaccharide-stimulated interleukin-1β and tumor necrosis factor α accumulation in primary astrocyte cultures.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 201 | Get Quote |
|
| 5MG | 312 | Get Quote |
|
| 10MG | 534 | Get Quote |
|
| 25MG | 1003 | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameFABPs ligand 6
-
NoteResearch use only, not for human use.
-
Brief DescriptionFABPs ligand 6 (MF6) is a selective inhibitor of FABP5 and FABP7 that reduces levels of oxidative stress in the mouse spinal cord as well as lipopolysaccharide-stimulated interleukin-1β and tumor necrosis factor α accumulation in primary astrocyte cultures.
-
DescriptionFABPs ligand 6 (MF6) is an FABP5 and FABP7 inhibitor with KD values of 874 nM and 20 nM, respectively. FABPs ligand 6 can be used for multiple sclerosis research.
-
In VitroFABPs ligand 6 (MF6) rescues mitochondrial function by blocking voltagedependent anion channel (VDAC)-1-dependent mitochondrial macropore formation induced by psychosine in KG-1C cells, a FABP5- mediated injury.
-
In VivoMF 6 (1 mg/kg; i.g.; daily for 4 weeks) improves the severity of EAE (experimental autoimmune encephalomyelitis) and attenuates oxidative levels and the inflammatory response.Animal Model:8-10-week-old female C57BMF/6J mice with MOG35-55-administered experimental autoimmune encephalomyelitis (EAE) mouse model Dosage:1 mg/kg Administration:Intragastric administration, daily for 4 weeks Result:Attenuated EAE symptoms, decreased oxidative stress, inhibited astrocyte activation and protected oligodendrocytes.
-
Synonyms——
-
PathwayMembrane Transporter/Ion Channel
-
TargetFABP
-
RecptorFABP
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number2988135-14-2
-
Formula Weight458.52
-
Molecular FormulaC28H27FN2O3
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?DMSO : 125 mg/mL (272.62 mM; Ultrasonic )
-
SMILESO=C(O)CCCOC=1C=CC(F)=CC1C2=NN(C3=CC=C(C=C3)C(C)C)C(=C2)C=4C=CC=CC4
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Cheng A, et al. A novel fatty acid-binding protein 5 and 7 inhibitor ameliorates oligodendrocyte injury in multiple sclerosis mouse models. EBioMedicine. 2021 Oct;72:103582. ?
molnova catalog
related products
-
FABPs ligand 6
FABPs ligand 6 (MF6) is a selective inhibitor of FABP5 and FABP7 that reduces levels of oxidative stress in the mouse spinal cord as well as lipopolysaccharide-stimulated interleukin-1β and tumor necrosis factor α accumulation in primary astrocyte cultures.
-
SBFI-26
SBFI-26 (SBFI26) is a small molecule inhibitor of epidermal- and brain-specific FABP5 and FABP7 that effectively increases anandamide signaling.
-
HTS 01037
HTS01037 is a highly potent ligand of adipocyte fatty acid binding protein (A-FABP/aP2) with Ki of 0.67 uM.
